CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery

........................................................................................... lay summary...................................................................................... svensk populärvetenskapliG sammanfattninG......................... abbreviations..................................................................................... introduCtion..................................................................................... THe MeSeNCepHALiC DOpAMiNeRgiC NeURON SySTeM...................... Anatomical description.................................................................. Functional anatomical description.................................................. MeSeNCepHALiC DOpAMiNeRgiC NeURONAL SUBTypeS...................... ORigiN OF MeSeNCepHALiC DOpAMiNeRgiC NeURONS....................... Development.................................................................................. Subtype development.................................................................... Formation of pathways.................................................................. SUBType CONCLUSiON....................................................................... Parkinson’s disease........................................................................ neuronal subtype vulnerability in Parkinson’s disease.................... Cell replacement therapy for Parkinson’s disease........................... Alternative cell sources.................................................................. aims of this thesis............................................................................ results and Comments.................................................................... paPer No1.......................................................................................... PaPer No2.......................................................................................... pApeR No3.......................................................................................... PaPer No4.......................................................................................... ConCludinG remarks and prospeCts............................................ materials and methods.................................................................. geNeRAL CONCeRNS.......................................................................... RATS................................................................................................. MiCe.................................................................................................. TRANSgeNiC MiCe............................................................................. HUMAN FeTAL TiSSUe......................................................................... 6-HyDROxyDOpAMiNe LeSiONS.........................................................